According to the DOJ and the DEA, it's virtually impossible.
From The Daily Dish...
A Department of Justice/DEA brief from 1988 reads:So exactly why is the Obama administration continuing the war on medical marijuana?
[A] marijuana smoker would have to consume 20,000 to 40,000 times as much marijuana as is contained in one marijuana cigarette. ... A smoker would theoretically have to consume nearly 1,500 pounds of marijuana within about fifteen minutes to induce a lethal response.
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